Time for a statistical crystallography
Can thousands of crystals reveal protein dynamics?
Summary of statistical crystallography of Mpro
Could we experimentally measure functional dynamics, like allostery, by perturbing and studying way more crystals than we had thought about previously?
We think the answer is yes.
Read more in my blog post, or see our preprint for full details:
https://www.biorxiv.org/content/10.1101/2025.01.28.635305v1.full.pdf