Careers

We are hiring! Please find below some open positions. If you are a PhD candidate currently at UHH or interested in a PhD at UHH, please consider these roles even if they are labeled "postdoc".

In addition we are always interested in hearing from PhD or postdoctoral candidates who are interested in joining our group for any reason. If you want to explore working together, email thomas [dot] lane [at] desy [dot] de and we can discuss! Looking forward to hearing from you :).

Understanding how proteins move by through multi-crystal analysis

Postdoctoral Position

We know proteins make use of long-range motions to perform the essential functions of life: transmit signals, conduct chemistry, and mechanically alter the environment, but how proteins accomplish these amazing tasks remains unexplained at the atomic level. Experimentally measuring these long-range motions at atomic detail has been a challenge. Recently, our group had success in doing this for the main protease (Mpro) from SARS-COV-2, the virus behind the COVID pandemic. Many datasets on COVID and non-COVID proteins have been collected, but new methods are necessary to investigate and extract information about protein motions in these data — we seek a computational scientist to drive this work.

As the ideal candidate, you will have the following key attributes:

  • A doctoral degree in physics, biophysics, computer science, or a related field
  • Excellent computational skills, including python and modern data science methods
  • Capabilities in computational crystallography (serial crystallography a bonus but not required)
  • Knowledge of the principles of protein structure and function
  • The ability to drive your work independently and show initiative

And you will be excited to take on the following responsibilities:

  • Writing software and scripting to perform data analysis on a daily basis
  • Working with large, rich crystallographic datasets from synchrotrons and XFELs
  • Analysis/interpretation of experimental data and results
  • Helping to foster an environment conducive to collaboration, learning, growth, and fun

The position offers a chance to work in a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science.

Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the beautiful and vibrant city of Hamburg, Germany.

For more details or to apply, write directly to TJ Lane and provide a CV and short introduction or cover letter.

Understanding enzyme catalysis by filming enzymes at atomic/fs resolution

Postdoctoral Position

Enzymes are the best performing catalysts on Earth, yet the details of their function — for example what role dynamics play or not in chemical rearrangements — remain a source of debate. New x-ray free electron laser (XFEL) technology allows us to directly image proteins at the time and length-scales (atoms/fs) on which chemistry occurs, making it possible to directly study enzyme catalyzed reactions via imaging. The photobiology group led by TJ Lane at CFEL seeks a postdoctoral candidate conduct this work on naturally occurring and man-made photoenzyme systems.

As the ideal candidate, you will have the following key attributes:

  • A doctoral degree in physics, chemistry, biochemistry, or a related field
  • Excellent wet-lab skills, with knowledge of how to produce, purify, and crystallize proteins
  • A basic familiarity with serial femtosecond crystallography and XFELs
  • Basic computational skills including unix-style environments, python/matlab/similar
  • The ability to drive your work independently and show initiative

And you will be excited to take on the following responsibilities:

  • Design of experiments, including new hardware and software when necessary
  • Organizing and leading teams of 2-20 people to conduct XFEL experiments
  • Preparation of protein crystal samples and wet lab bio/chemistry
  • Interpretation and analysis of experimental results
  • Helping to foster an environment conducive to collaboration, learning, growth, and fun

The position offers a chance to work in a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science.

Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the beautiful and vibrant city of Hamburg, Germany.

For more details or to apply, write directly to TJ Lane and provide a CV and short introduction or cover letter.

Understanding and controlling enzyme catalysis through design of photoactive compounds

Postdoctoral Position

Enzymes are the best known catalysts on Earth. The photobiology group led by TJ Lane at CFEL seeks a postdoctoral candidate to develop new chemical technology that will turn regular enzymes into photoenzymes, where the reaction requires light. This enables spatio-temporal control of enzyme chemistry in the biological context, as we can use a laser to initiate the reaction — opening opportunities for learning about how enzymes do their magic both in vitro and in vivo.

As the ideal candidate, you will have the following key attributes:

  • A doctoral degree in chemistry, biochemistry, or a related field
  • Experience working with proteins and biochemical assays
  • Chemical intuition and basic knowledge of organic chemistry and synthesis
  • An undergraduate-level or higher understanding of quantum mechanical principles and how they relate to photochemical behavior
  • The ability to drive your work independently and show initiative

And you will be excited to take on the following responsibilities:

  • Identifying the most important scientific questions in the field of enzyme catalysis
  • Design of experiments, including new hardware and software when necessary
  • Develop new biochemical assays
  • Develop high-throughput screens for new photo-active chemical matter
  • Collaborate with computational chemists to develop new compound designs
  • Helping to foster an environment conducive to collaboration, learning, growth, and fun

The position offers a chance to work in a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science.

Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the beautiful and vibrant city of Hamburg, Germany.

For more details or to apply, write directly to TJ Lane and provide a CV and short introduction or cover letter.